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Journal Article · · Plants
DOI:https://doi.org/10.3390/plants13243576· OSTI ID:2483766
Aldana-Mejía, Jennyfer A.
Ribeiro, Victor Pena
Katragunta, Kumar
Avula, Bharathi
Bastos, Jairo Kenupp
Khan, Ikhlas A.
Ross, Samir A.
Green propolis, particularly from the unique flora of the Brazilian Caatinga biome, has gained significant interest due to its diverse chemical composition and biological activities. This study focuses on the chemical characterization and antimicrobial evaluation of Caatinga green propolis. Twelve compounds were isolated through different chromatographic techniques, including flavanones (naringenin, 7-O-methyleriodictyol, sakuranetin), flavones (hispidulin, cirsimaritin), flavonols (quercetin, quercetin-3-methyl ether, kaempferol, 6-methoxykaempferol, viscosine, penduletin), and one chalcone (kukulkanin B). Using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS), a total of 55 compounds excluding reference standards were tentatively identified, which include flavonoids, phenolic acids derivatives, and alkaloids, with flavonols, flavanones, and flavones being predominant. Antimicrobial testing against pathogens revealed that the crude extract exhibited low inhibitory activity, against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) (IC50: 148.4 and 120.98 µg/mL, respectively). Although the isolated compounds showed limited individual activity, a fraction containing sakuranetin and penduletin (Fraction 8) exhibited moderated activity against Cryptococcus neoformans (IC50: 47.86 µg/mL), while a fraction containing quercetin and hispidulin showed moderated activity against VRE (IC50: 16.99 µg/mL). These findings highlight the potential application of Caatinga green propolis as an antimicrobial agent, particularly against resistant bacterial strains, and underscore the importance of synergistic interactions between compounds in enhancing biological effects.
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Aldana-Mejía, Jennyfer A., et al. "Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome." Plants, vol. 13, no. 24, Dec. 2024. https://doi.org/10.3390/plants13243576
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Aldana-Mejía, Jennyfer A., Ribeiro, Victor Pena, Katragunta, Kumar, Avula, Bharathi, Tatapudi, Kiran Kumar, Bastos, Jairo Kenupp, Khan, Ikhlas A., Meepagala, Kumudini, & Ross, Samir A. (2024). Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome. Plants, 13(24). https://doi.org/10.3390/plants13243576
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Aldana-Mejía, Jennyfer A., Ribeiro, Victor Pena, Katragunta, Kumar, et al., "Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome," Plants 13, no. 24 (2024), https://doi.org/10.3390/plants13243576
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@article{osti_2483766, author = {Aldana-Mejía, Jennyfer A. and Ribeiro, Victor Pena and Katragunta, Kumar and Avula, Bharathi and Tatapudi, Kiran Kumar and Bastos, Jairo Kenupp and Khan, Ikhlas A. and Meepagala, Kumudini and Ross, Samir A.}, title = {Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome}, annote = {Green propolis, particularly from the unique flora of the Brazilian Caatinga biome, has gained significant interest due to its diverse chemical composition and biological activities. This study focuses on the chemical characterization and antimicrobial evaluation of Caatinga green propolis. Twelve compounds were isolated through different chromatographic techniques, including flavanones (naringenin, 7-O-methyleriodictyol, sakuranetin), flavones (hispidulin, cirsimaritin), flavonols (quercetin, quercetin-3-methyl ether, kaempferol, 6-methoxykaempferol, viscosine, penduletin), and one chalcone (kukulkanin B). Using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS), a total of 55 compounds excluding reference standards were tentatively identified, which include flavonoids, phenolic acids derivatives, and alkaloids, with flavonols, flavanones, and flavones being predominant. Antimicrobial testing against pathogens revealed that the crude extract exhibited low inhibitory activity, against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) (IC50: 148.4 and 120.98 µg/mL, respectively). Although the isolated compounds showed limited individual activity, a fraction containing sakuranetin and penduletin (Fraction 8) exhibited moderated activity against Cryptococcus neoformans (IC50: 47.86 µg/mL), while a fraction containing quercetin and hispidulin showed moderated activity against VRE (IC50: 16.99 µg/mL). These findings highlight the potential application of Caatinga green propolis as an antimicrobial agent, particularly against resistant bacterial strains, and underscore the importance of synergistic interactions between compounds in enhancing biological effects.}, doi = {10.3390/plants13243576}, url = {https://www.osti.gov/biblio/2483766}, journal = {Plants}, issn = {ISSN 2223-7747}, number = {24}, volume = {13}, place = {Netherlands}, publisher = {MDPI AG}, year = {2024}, month = {12}}
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- MLA
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Aldana-Mejía, Jennyfer A., et al. "Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome." Plants, vol. 13, no. 24, Dec. 2024. https://doi.org/10.3390/plants13243576
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Aldana-Mejía, Jennyfer A., Ribeiro, Victor Pena, Katragunta, Kumar, Avula, Bharathi, Tatapudi, Kiran Kumar, Bastos, Jairo Kenupp, Khan, Ikhlas A., Meepagala, Kumudini, & Ross, Samir A. (2024). Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome. Plants, 13(24). https://doi.org/10.3390/plants13243576
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Aldana-Mejía, Jennyfer A., Ribeiro, Victor Pena, Katragunta, Kumar, et al., "Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome," Plants 13, no. 24 (2024), https://doi.org/10.3390/plants13243576
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@article{osti_2483766, author = {Aldana-Mejía, Jennyfer A. and Ribeiro, Victor Pena and Katragunta, Kumar and Avula, Bharathi and Tatapudi, Kiran Kumar and Bastos, Jairo Kenupp and Khan, Ikhlas A. and Meepagala, Kumudini and Ross, Samir A.}, title = {Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome}, annote = {Green propolis, particularly from the unique flora of the Brazilian Caatinga biome, has gained significant interest due to its diverse chemical composition and biological activities. This study focuses on the chemical characterization and antimicrobial evaluation of Caatinga green propolis. Twelve compounds were isolated through different chromatographic techniques, including flavanones (naringenin, 7-O-methyleriodictyol, sakuranetin), flavones (hispidulin, cirsimaritin), flavonols (quercetin, quercetin-3-methyl ether, kaempferol, 6-methoxykaempferol, viscosine, penduletin), and one chalcone (kukulkanin B). Using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS), a total of 55 compounds excluding reference standards were tentatively identified, which include flavonoids, phenolic acids derivatives, and alkaloids, with flavonols, flavanones, and flavones being predominant. Antimicrobial testing against pathogens revealed that the crude extract exhibited low inhibitory activity, against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) (IC50: 148.4 and 120.98 µg/mL, respectively). Although the isolated compounds showed limited individual activity, a fraction containing sakuranetin and penduletin (Fraction 8) exhibited moderated activity against Cryptococcus neoformans (IC50: 47.86 µg/mL), while a fraction containing quercetin and hispidulin showed moderated activity against VRE (IC50: 16.99 µg/mL). These findings highlight the potential application of Caatinga green propolis as an antimicrobial agent, particularly against resistant bacterial strains, and underscore the importance of synergistic interactions between compounds in enhancing biological effects.}, doi = {10.3390/plants13243576}, url = {https://www.osti.gov/biblio/2483766}, journal = {Plants}, issn = {ISSN 2223-7747}, number = {24}, volume = {13}, place = {Netherlands}, publisher = {MDPI AG}, year = {2024}, month = {12}}
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References (38)
Similar Records / Subjects
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- SC0014664
- OSTI ID:
- 2483766
- Journal Information:
- Plants, Journal Name: Plants Vol. 13 Journal Issue: 24; ISSN 2223-7747
- Publisher:
- MDPI AGCopyright Statement
- Country of Publication:
- Netherlands
- Language:
- English
References (38)
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