Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome (Journal Article) (2025)

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Citation Formats MLA APA Chicago BibTeX Aldana-Mejía, Jennyfer A., et al. "Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome." Plants, vol. 13, no. 24, Dec. 2024. https://doi.org/10.3390/plants13243576 🗎 Copy to clipboard Aldana-Mejía, Jennyfer A., Ribeiro, Victor Pena, Katragunta, Kumar, Avula, Bharathi, Tatapudi, Kiran Kumar, Bastos, Jairo Kenupp, Khan, Ikhlas A., Meepagala, Kumudini, & Ross, Samir A. (2024). Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome. Plants, 13(24). https://doi.org/10.3390/plants13243576 🗎 Copy to clipboard Aldana-Mejía, Jennyfer A., Ribeiro, Victor Pena, Katragunta, Kumar, et al., "Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome," Plants 13, no. 24 (2024), https://doi.org/10.3390/plants13243576 🗎 Copy to clipboard @article{osti_2483766, author = {Aldana-Mejía, Jennyfer A. and Ribeiro, Victor Pena and Katragunta, Kumar and Avula, Bharathi and Tatapudi, Kiran Kumar and Bastos, Jairo Kenupp and Khan, Ikhlas A. and Meepagala, Kumudini and Ross, Samir A.}, title = {Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome}, annote = {Green propolis, particularly from the unique flora of the Brazilian Caatinga biome, has gained significant interest due to its diverse chemical composition and biological activities. This study focuses on the chemical characterization and antimicrobial evaluation of Caatinga green propolis. Twelve compounds were isolated through different chromatographic techniques, including flavanones (naringenin, 7-O-methyleriodictyol, sakuranetin), flavones (hispidulin, cirsimaritin), flavonols (quercetin, quercetin-3-methyl ether, kaempferol, 6-methoxykaempferol, viscosine, penduletin), and one chalcone (kukulkanin B). Using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS), a total of 55 compounds excluding reference standards were tentatively identified, which include flavonoids, phenolic acids derivatives, and alkaloids, with flavonols, flavanones, and flavones being predominant. Antimicrobial testing against pathogens revealed that the crude extract exhibited low inhibitory activity, against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) (IC50: 148.4 and 120.98 µg/mL, respectively). Although the isolated compounds showed limited individual activity, a fraction containing sakuranetin and penduletin (Fraction 8) exhibited moderated activity against Cryptococcus neoformans (IC50: 47.86 µg/mL), while a fraction containing quercetin and hispidulin showed moderated activity against VRE (IC50: 16.99 µg/mL). These findings highlight the potential application of Caatinga green propolis as an antimicrobial agent, particularly against resistant bacterial strains, and underscore the importance of synergistic interactions between compounds in enhancing biological effects.}, doi = {10.3390/plants13243576}, url = {https://www.osti.gov/biblio/2483766}, journal = {Plants}, issn = {ISSN 2223-7747}, number = {24}, volume = {13}, place = {Netherlands}, publisher = {MDPI AG}, year = {2024}, month = {12}} 🗎 Copy to clipboard References (38) Similar Records Related Subjects

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Aldana-Mejía, Jennyfer A.
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Ribeiro, Victor Pena
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Katragunta, Kumar
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Avula, Bharathi
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Tatapudi, Kiran Kumar;
Bastos, Jairo Kenupp
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Khan, Ikhlas A.
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Meepagala, Kumudini;
Ross, Samir A.
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Green propolis, particularly from the unique flora of the Brazilian Caatinga biome, has gained significant interest due to its diverse chemical composition and biological activities. This study focuses on the chemical characterization and antimicrobial evaluation of Caatinga green propolis. Twelve compounds were isolated through different chromatographic techniques, including flavanones (naringenin, 7-O-methyleriodictyol, sakuranetin), flavones (hispidulin, cirsimaritin), flavonols (quercetin, quercetin-3-methyl ether, kaempferol, 6-methoxykaempferol, viscosine, penduletin), and one chalcone (kukulkanin B). Using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS), a total of 55 compounds excluding reference standards were tentatively identified, which include flavonoids, phenolic acids derivatives, and alkaloids, with flavonols, flavanones, and flavones being predominant. Antimicrobial testing against pathogens revealed that the crude extract exhibited low inhibitory activity, against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) (IC50: 148.4 and 120.98 µg/mL, respectively). Although the isolated compounds showed limited individual activity, a fraction containing sakuranetin and penduletin (Fraction 8) exhibited moderated activity against Cryptococcus neoformans (IC50: 47.86 µg/mL), while a fraction containing quercetin and hispidulin showed moderated activity against VRE (IC50: 16.99 µg/mL). These findings highlight the potential application of Caatinga green propolis as an antimicrobial agent, particularly against resistant bacterial strains, and underscore the importance of synergistic interactions between compounds in enhancing biological effects.

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  • APA
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Aldana-Mejía, Jennyfer A., et al. "Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome." Plants, vol. 13, no. 24, Dec. 2024. https://doi.org/10.3390/plants13243576

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Aldana-Mejía, Jennyfer A., Ribeiro, Victor Pena, Katragunta, Kumar, Avula, Bharathi, Tatapudi, Kiran Kumar, Bastos, Jairo Kenupp, Khan, Ikhlas A., Meepagala, Kumudini, & Ross, Samir A. (2024). Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome. Plants, 13(24). https://doi.org/10.3390/plants13243576

🗎 Copy to clipboard

Aldana-Mejía, Jennyfer A., Ribeiro, Victor Pena, Katragunta, Kumar, et al., "Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome," Plants 13, no. 24 (2024), https://doi.org/10.3390/plants13243576

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@article{osti_2483766, author = {Aldana-Mejía, Jennyfer A. and Ribeiro, Victor Pena and Katragunta, Kumar and Avula, Bharathi and Tatapudi, Kiran Kumar and Bastos, Jairo Kenupp and Khan, Ikhlas A. and Meepagala, Kumudini and Ross, Samir A.}, title = {Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome}, annote = {Green propolis, particularly from the unique flora of the Brazilian Caatinga biome, has gained significant interest due to its diverse chemical composition and biological activities. This study focuses on the chemical characterization and antimicrobial evaluation of Caatinga green propolis. Twelve compounds were isolated through different chromatographic techniques, including flavanones (naringenin, 7-O-methyleriodictyol, sakuranetin), flavones (hispidulin, cirsimaritin), flavonols (quercetin, quercetin-3-methyl ether, kaempferol, 6-methoxykaempferol, viscosine, penduletin), and one chalcone (kukulkanin B). Using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS), a total of 55 compounds excluding reference standards were tentatively identified, which include flavonoids, phenolic acids derivatives, and alkaloids, with flavonols, flavanones, and flavones being predominant. Antimicrobial testing against pathogens revealed that the crude extract exhibited low inhibitory activity, against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) (IC50: 148.4 and 120.98 µg/mL, respectively). Although the isolated compounds showed limited individual activity, a fraction containing sakuranetin and penduletin (Fraction 8) exhibited moderated activity against Cryptococcus neoformans (IC50: 47.86 µg/mL), while a fraction containing quercetin and hispidulin showed moderated activity against VRE (IC50: 16.99 µg/mL). These findings highlight the potential application of Caatinga green propolis as an antimicrobial agent, particularly against resistant bacterial strains, and underscore the importance of synergistic interactions between compounds in enhancing biological effects.}, doi = {10.3390/plants13243576}, url = {https://www.osti.gov/biblio/2483766}, journal = {Plants}, issn = {ISSN 2223-7747}, number = {24}, volume = {13}, place = {Netherlands}, publisher = {MDPI AG}, year = {2024}, month = {12}}

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References (38)

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Sponsoring Organization:
USDOE
Grant/Contract Number:
SC0014664
OSTI ID:
2483766
Journal Information:
Plants, Journal Name: Plants Vol. 13 Journal Issue: 24; ISSN 2223-7747
Publisher:
MDPI AGCopyright Statement
Country of Publication:
Netherlands
Language:
English

References (38)

Brazilian red propolis improves cutaneous wound healing suppressing inflammation-associated transcription factor NFκB journal February 2017
Kukulkanins A and B, New Chalcones from Mimosa tenuefolia journal July 1989
Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba journal June 2012
Propolis: a new frontier for wound healing? journal July 2015
Unraveling the metabolomic profile and acute toxicity of ethanolic extract from Mimosa tenuiflora (Willd.) Poir. root bark journal October 2024
Antioxidant Activity and Determination of Phenolic Compounds, Total Flavonoids and Hispidulin in Baccharis erioclada DC. journal January 2023
Antioxidant Activity of a Geopropolis from Northeast Brazil: Chemical Characterization and Likely Botanical Origin
  • Ferreira, Joselena M.; Fernandes-Silva, Caroline C.; Salatino, Antonio
  • Evidence-Based Complementary and Alternative Medicine, Vol. 2017, Issue 1 https://doi.org/10.1155/2017/4024721
journal January 2017
O-Demethylation and Sulfation of 7-Methoxylated Flavanones by Cunninghamella elegans. journal January 2003
STUDY OF FLAVONOIDS PRESENT IN POMELO (Citrus Maxima) BY DSC, UV-VIS, IR, 1H AND 13C NMR AND MS journal August 2017
Dataset on the compounds from the leaves of Vietnamese Machilus thunbergii and their anti-inflammatory activity journal December 2023
Polyphenol profile by UHPLC-MS/MS, anti-glycation, antioxidant and cytotoxic activities of several samples of propolis from the northeastern semi-arid region of Brazil journal January 2017
New propolis type from north‐east Brazil: chemical composition, antioxidant activity and botanical origin
  • Ferreira, Joselena M.; Fernandes‐Silva, Caroline C.; Salatino, Antonio
  • Journal of the Science of Food and Agriculture, Vol. 97, Issue 11 https://doi.org/10.1002/jsfa.8210
journal February 2017
Phytochemistry and teratogenic potential of Mimosa tenuiflora (willd.) poir. (Fabaceae) in ruminants: A systematic review journal May 2021
Propolis research and the chemistry of plant products journal January 2011
Chemical Evaluation of Betula Species in Japan. III. Constituents of Betula maximowicziana. journal January 1996
Anti-fungal and antioxidant properties of propolis (bee glue) extracts journal January 2022
How diverse is the chemistry and plant origin of Brazilian propolis? journal October 2021
Epidemiology of Vancomycin-Resistant Enterococcus faecium and Enterococcus faecalis Colonization in Nursing Facilities journal January 2020
Quantification and Characterization of Phenolic Compounds from Northern Indian Propolis Extracts and Dietary Supplements journal March 2020
The phytochemistry of the honeybee journal November 2018
Brazilian Red Propolis—Chemical Composition and Botanical Origin journal December 2006
Herbicide determination in Brazilian propolis using high pressure liquid chromatography journal October 2019
Effects of caatinga propolis from Mimosa tenuiflora and its constituents (santin, sakuranetin and kaempferide) on human immune cells journal January 2024
Phytochemical and biological evaluation of Salvia apiana journal December 2016
Brazilian red propolis in combination with β-lactams exerts an efficient antibacterial action over methicillin-resistantStaphylococcus aureus(MRSA) strains journal December 2022
Leismanicidal Activity of Propolis Collected in the Semiarid Region of Brazil journal July 2021
HMDB 5.0: the Human Metabolome Database for 2022 journal November 2021
Propolis: Is there a potential for the development of new drugs? journal January 2011
Phytochemical, Antiplasmodial, Cytotoxic and Antimicrobial Evaluation of a Southeast Brazilian Brown Propolis Produced by Apis mellifera Bees journal July 2021
Flavonoids from Mimosa tenuiflora Green Propolis: Chemotaxonomy, Antioxidant, Anti‐Inflammation, Anti‐Bacteria, Mosquito Larvicidal Activity, and In Silico Approach journal June 2024
Flavonoids from green propolis of the Northeastern Brazilian Caatinga Mimosa tenuiflora (Willd.) Poir.: A chemotaxonomic aspect journal October 2022
Chemical characterization, antioxidant and anti-HIV activities of a Brazilian propolis from Ceará state journal May 2019
Chemical study of Mimosa tenuiflora barks journal September 2020
A validated HPLC-UV method for the analysis of phenolic compounds in Brazilian red propolis and Dalbergia ecastaphyllum journal May 2021
Chemical Constituents of Red Mexican Propolis journal February 2010
A Validated RP-HPLC–DAD Method for Analyzing Flavonoids in Caatinga Brazilian Green Propolis from Mimosa tenuiflora Produced by Apis mellifera journal November 2024
Antimicrobial potential of Jurema preta and umburana, native species of the Caatinga biome, on Staphylococcus isolated from small ruminants with mastitis journal August 2020
Green Propolis: Cytotoxic and Leishmanicidal Activities of Artepillin C, p-Coumaric Acid, and Their Degradation Products journal March 2020

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